| Tissue Specificity | Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. |
| Function | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs).is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. |
| Protein Name | C-Type Lectin Domain Family 4 Member KLangerinCd Antigen Cd207 |
| Database Links | Reactome: R-HSA-1236978 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinFound In Birbeck Granules (Bgs)Which Are Organelles Consisting Of Superimposed And Zippered Membranes |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member K antibodyAnti-Langerin antibodyAnti-Cd Antigen Cd207 antibodyAnti-CD207 antibodyAnti-CLEC4K antibody |
Information sourced from Uniprot.org
