Anti-Langerin antibody [12D6] (STJ16101823)

SKU:
STJ16101823-1

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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Langerin is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 12D6
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: Tissue culture supernatant with sodium azide
Concentration: >=20 mg/L
Dilution Range: IHC-P 1:50
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CD207
Gene ID: 50489
Uniprot ID: CLC4K_HUMAN
Immunogen: Prokaryotic recombinant protein of 29 kD corresponding to the external domain of the langerin molecule.
Tissue Specificity Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Function Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs).is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Protein Name C-Type Lectin Domain Family 4 Member K
Langerin
Cd Antigen Cd207
Database Links Reactome: R-HSA-1236978
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Found In Birbeck Granules (Bgs)
Which Are Organelles Consisting Of Superimposed And Zippered Membranes
Alternative Antibody Names Anti-C-Type Lectin Domain Family 4 Member K antibody
Anti-Langerin antibody
Anti-Cd Antigen Cd207 antibody
Anti-CD207 antibody
Anti-CLEC4K antibody

Information sourced from Uniprot.org

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