Anti-Langerin antibody [12D6] (STJ16101437)

Anti-Langerin antibody [12D6] (STJ16101437)

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STJ16101437-1
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Short Description :Mouse monoclonal anti-Langerin for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-P
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :12D6
Isotype:IgG2bk
Conjugation:Unconjugated
Dilution Range:IHC-P 1:100-1:500
Formulation:Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage Instruction:Store at 2-8°C for up to 1-year, upon receipt.
Gene Symbol:CD207
Gene ID:50489
Uniprot ID:CLC4K_HUMAN
Tissue Specificity Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Function Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs).is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Protein Name C-Type Lectin Domain Family 4 Member K
Langerin
Cd Antigen Cd207
Database Links Reactome: R-HSA-1236978
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Found In Birbeck Granules (Bgs)
Which Are Organelles Consisting Of Superimposed And Zippered Membranes
Alternative Antibody Names Anti-C-Type Lectin Domain Family 4 Member K antibody
Anti-Langerin antibody
Anti-Cd Antigen Cd207 antibody
Anti-CD207 antibody
Anti-CLEC4K antibody

Information sourced from Uniprot.org

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