| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
LAMTOR3 |
| Gene ID: |
8649 |
| Uniprot ID: |
LTOR3_HUMAN |
| Immunogen Region: |
1-124 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human LAMTOR3 (NP_068805.1). |
| Immunogen Sequence: |
MADDLKRFLYKKLPSVEGLH AIVVSDRDGVPVIKVANDNA PEHALRPGFLSTFALATDQG SKLGLSKNKSIICYYNTYQV VQFNRLPLVVSFIASSSANT GLIVSLEKELAPLFEELRQV VEVS |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. |
| Protein Name | Ragulator Complex Protein Lamtor3Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 3Mek-Binding Partner 1Mp1Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1Mitogen-Activated Protein Kinase Scaffold Protein 1 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinCytoplasmic SideRecruited To Lysosome And Endosome Membranes By Lamtor1 |
| Alternative Antibody Names | Anti-Ragulator Complex Protein Lamtor3 antibodyAnti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 3 antibodyAnti-Mek-Binding Partner 1 antibodyAnti-Mp1 antibodyAnti-Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1 antibodyAnti-Mitogen-Activated Protein Kinase Scaffold Protein 1 antibodyAnti-LAMTOR3 antibodyAnti-MAP2K1IP1 antibodyAnti-MAPKSP1 antibodyAnti-PRO2783 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
