| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. |
| Protein Name | Ragulator Complex Protein Lamtor3Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 3Mek-Binding Partner 1Mp1Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1Mitogen-Activated Protein Kinase Scaffold Protein 1 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinCytoplasmic SideRecruited To Lysosome And Endosome Membranes By Lamtor1 |
| Alternative Antibody Names | Anti-Ragulator Complex Protein Lamtor3 antibodyAnti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 3 antibodyAnti-Mek-Binding Partner 1 antibodyAnti-Mp1 antibodyAnti-Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1 antibodyAnti-Mitogen-Activated Protein Kinase Scaffold Protein 1 antibodyAnti-LAMTOR3 antibodyAnti-MAP2K1IP1 antibodyAnti-MAPKSP1 antibodyAnti-PRO2783 antibody |
Information sourced from Uniprot.org
