| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LAMP3 (140-380) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LAMP3 |
| Gene ID: |
27074 |
| Uniprot ID: |
LAMP3_HUMAN |
| Immunogen Region: |
140-380 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 140-380 of human LAMP3 (NP_055213.2). |
| Immunogen Sequence: |
PPAHTTGTSSSTVSHTTGNT TQPSNQTTLPATLSIALHKS TTGQKPVQPTHAPGTTAAAH NTTRTAAPASTVPGPTLAPQ PSSVKTGIYQVLNGSRLCIK AEMGIQLIVQDKESVFSPRR YFNIDPNATQASGNCGTRKS NLLLNFQGGFVNLTFTKDEE SYYISEVGAYLTVSDPETIY QGIKHAVVMFQTAVGHSFKC VSEQSLQLSAHLQVKTTDVQ LQAFDFEDDHFGNVDECSS |
| Tissue Specificity | Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. |
| Function | Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity. (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium. |
| Protein Name | Lysosome-Associated Membrane Glycoprotein 3Lamp-3Lysosomal-Associated Membrane Protein 3Dc-Lysosome-Associated Membrane GlycoproteinDc LampProtein Tsc403Cd Antigen Cd208 |
| Cellular Localisation | Cell SurfaceLysosome MembraneSingle-Pass Type I Membrane ProteinCytoplasmic Vesicle MembraneEarly Endosome MembraneDuring Dendritic Cell MaturationDetected On Cytoplasmic Vesicles (The Mhc Ii Compartment) That Contain Mhc Ii ProteinsLamp1Lamp2 And Lamp3Detected On Lysosomes In Mature Dendritic Cells |
| Alternative Antibody Names | Anti-Lysosome-Associated Membrane Glycoprotein 3 antibodyAnti-Lamp-3 antibodyAnti-Lysosomal-Associated Membrane Protein 3 antibodyAnti-Dc-Lysosome-Associated Membrane Glycoprotein antibodyAnti-Dc Lamp antibodyAnti-Protein Tsc403 antibodyAnti-Cd Antigen Cd208 antibodyAnti-LAMP3 antibodyAnti-DCLAMP antibodyAnti-TSC403 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
