Anti-Laminin Beta 2/Gamma 1 Subunits Antibody antibody [M046] (STJA0041262)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenClone (M046) was generated from a recombinant human laminin 521 protein that includes a heterotrimer of three subunits laminin Alpha 5, laminin Beta 2, and laminin Gamma 1 subunits.
General Information
| Short Description | Mouse monoclonal anti-Laminin Beta 2/Gamma 1 Subunits antibody for use in ELISA, WB-Nat and ICC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB-Nat/ICC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | M046 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Purification | Protein A Purified |
| Dilution Range | WB 1:1000ICC 1:200 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C. |
Target Information
| Gene Symbol | LAMC1 |
| Gene ID | 3915 |
| Uniprot ID | LAMC1_HUMAN |
| Immunogen | Clone (M046) was generated from a recombinant human laminin 521 protein that includes a heterotrimer of three subunits laminin Alpha 5, laminin Beta 2, and laminin Gamma 1 subunits. |
| Immunogen Sequence | Human |
| Specificity | Clone M046 detects native laminin isoforms that include both laminin Beta 2 and Gamma 1 subunits. In native immunoblots, the antibody detects laminin 521, laminin 221, and laminin 121, but does not detect lamin 332 and laminin 411. The antibody weakl |
Additional Info
| Tissue Specificity | Found in the basement membranes (major component). |
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Protein Name | Laminin Subunit Gamma-1Laminin B2 ChainLaminin-1 Subunit GammaLaminin-10 Subunit GammaLaminin-11 Subunit GammaLaminin-2 Subunit GammaLaminin-3 Subunit GammaLaminin-4 Subunit GammaLaminin-6 Subunit GammaLaminin-7 Subunit GammaLaminin-8 Subunit GammaLaminin-9 Subunit GammaS-Laminin Subunit GammaS-Lam Gamma |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-373760Reactome: R-HSA-381426Reactome: R-HSA-8874081Reactome: R-HSA-8957275Reactome: R-HSA-9619665Reactome: R-HSA-9913351 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement Membrane |
| Alternative Antibody Names | Anti-Laminin Subunit Gamma-1 antibodyAnti-Laminin B2 Chain antibodyAnti-Laminin-1 Subunit Gamma antibodyAnti-Laminin-10 Subunit Gamma antibodyAnti-Laminin-11 Subunit Gamma antibodyAnti-Laminin-2 Subunit Gamma antibodyAnti-Laminin-3 Subunit Gamma antibodyAnti-Laminin-4 Subunit Gamma antibodyAnti-Laminin-6 Subunit Gamma antibodyAnti-Laminin-7 Subunit Gamma antibodyAnti-Laminin-8 Subunit Gamma antibodyAnti-Laminin-9 Subunit Gamma antibodyAnti-S-Laminin Subunit Gamma antibodyAnti-S-Lam Gamma antibodyAnti-LAMC1 antibodyAnti-LAMB2 antibody |
Information sourced from Uniprot.org