| Short Description : | Mouse monoclonal anti-Laminin Beta 2/Gamma 1 Subunits antibody for use in ELISA, WB-Nat and ICC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | ELISA/WB-Nat/ICC |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | M046 |
| Isotype: | IgG2b |
| Conjugation: | Unconjugated |
| Purification: | Protein A Purified |
| Dilution Range: | WB 1:1000ICC 1:200 |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction: | Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C. |
| Gene Symbol: | LAMC1 |
| Gene ID: | 3915 |
| Uniprot ID: | LAMC1_HUMAN |
| Immunogen: | Clone (M046) was generated from a recombinant human laminin 521 protein that includes a heterotrimer of three subunits laminin Alpha 5, laminin Beta 2, and laminin Gamma 1 subunits. |
| Immunogen Sequence: | Human |
| Specificity: | Clone M046 detects native laminin isoforms that include both laminin Beta 2 and Gamma 1 subunits. In native immunoblots, the antibody detects laminin 521, laminin 221, and laminin 121, but does not detect lamin 332 and laminin 411. The antibody weakl |
| Tissue Specificity | Found in the basement membranes (major component). |
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Protein Name | Laminin Subunit Gamma-1Laminin B2 ChainLaminin-1 Subunit GammaLaminin-10 Subunit GammaLaminin-11 Subunit GammaLaminin-2 Subunit GammaLaminin-3 Subunit GammaLaminin-4 Subunit GammaLaminin-6 Subunit GammaLaminin-7 Subunit GammaLaminin-8 Subunit GammaLaminin-9 Subunit GammaS-Laminin Subunit GammaS-Lam Gamma |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-373760Reactome: R-HSA-381426Reactome: R-HSA-8874081Reactome: R-HSA-8957275Reactome: R-HSA-9619665Reactome: R-HSA-9913351 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement Membrane |
| Alternative Antibody Names | Anti-Laminin Subunit Gamma-1 antibodyAnti-Laminin B2 Chain antibodyAnti-Laminin-1 Subunit Gamma antibodyAnti-Laminin-10 Subunit Gamma antibodyAnti-Laminin-11 Subunit Gamma antibodyAnti-Laminin-2 Subunit Gamma antibodyAnti-Laminin-3 Subunit Gamma antibodyAnti-Laminin-4 Subunit Gamma antibodyAnti-Laminin-6 Subunit Gamma antibodyAnti-Laminin-7 Subunit Gamma antibodyAnti-Laminin-8 Subunit Gamma antibodyAnti-Laminin-9 Subunit Gamma antibodyAnti-S-Laminin Subunit Gamma antibodyAnti-S-Lam Gamma antibodyAnti-LAMC1 antibodyAnti-LAMB2 antibody |
Information sourced from Uniprot.org
