| Host: | Rabbit |
| Applications: | WB/FC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-Laminin beta 1 for use in WB and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R08-7I6 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000FC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | LAMB1 |
| Gene ID: | 3912 |
| Uniprot ID: | LAMB1_HUMAN |
| Immunogen: | A synthesized peptide derived from human Laminin beta 1 |
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. |
| Protein Name | Laminin Subunit Beta-1Laminin B1 ChainLaminin-1 Subunit BetaLaminin-10 Subunit BetaLaminin-12 Subunit BetaLaminin-2 Subunit BetaLaminin-6 Subunit BetaLaminin-8 Subunit Beta |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-373760Reactome: R-HSA-381426Reactome: R-HSA-8874081Reactome: R-HSA-8957275Reactome: R-HSA-9619665Reactome: R-HSA-9913351 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMajor Component |
| Alternative Antibody Names | Anti-Laminin Subunit Beta-1 antibodyAnti-Laminin B1 Chain antibodyAnti-Laminin-1 Subunit Beta antibodyAnti-Laminin-10 Subunit Beta antibodyAnti-Laminin-12 Subunit Beta antibodyAnti-Laminin-2 Subunit Beta antibodyAnti-Laminin-6 Subunit Beta antibodyAnti-Laminin-8 Subunit Beta antibodyAnti-LAMB1 antibody |
Information sourced from Uniprot.org