| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-L3MBTL1 (550-600 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
L3MBTL1 |
| Gene ID: |
26013 |
| Uniprot ID: |
LMBL1_HUMAN |
| Immunogen Region: |
550-600 aa |
| Specificity: |
Specific for L3MBTL1. |
| Immunogen: |
A synthetic peptide from aa region 550-600 of human L3MBTL1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Ubiquitinated in a VCP/p97-dependent way following DNA damage, leading to its removal from DNA damage sites, promoting accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited to DNA damage sites. |
| Function | Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. |
| Protein Name | Lethal(3malignant Brain Tumor-Like Protein 1H-L(3mbtH-L(3mbt ProteinL(3mbt-LikeL(3mbt Protein HomologL3mbtl1 |
| Database Links | Reactome: R-HSA-6804760 |
| Cellular Localisation | NucleusExcluded From The NucleolusDoes Not Colocalize With The Pcg Protein Bmi1Suggesting That These Two Proteins Do Not Belong To The Same Complex |
| Alternative Antibody Names | Anti-Lethal(3malignant Brain Tumor-Like Protein 1 antibodyAnti-H-L(3mbt antibodyAnti-H-L(3mbt Protein antibodyAnti-L(3mbt-Like antibodyAnti-L(3mbt Protein Homolog antibodyAnti-L3mbtl1 antibodyAnti-L3MBTL1 antibodyAnti-KIAA0681 antibodyAnti-L3MBT antibodyAnti-L3MBTL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
