Anti-L-Plastin/LCP1 antibody (528-627) [S2MR] (STJ11103572)

Name: Anti-L-Plastin/LCP1 antibody (528-627) [S2MR] (STJ11103572)
SKU: STJ11103572
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103572

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Short Description	Rabbit monoclonal L-Plastin/LCP1 (528-627) antibody for use in WB, IHC-P and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S2MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	LCP1
Gene ID	3936
Uniprot ID	PLSL_HUMAN
Immunogen Region	528-627
Immunogen Sequence	TLREAKKSSSISSFKDPKIS TSLPVLDLIDAIQPGSINYD LLKTENLNDDEKLNNAKYAI SMARKIGARVYALPEDLVEV NPKMVMTVFACLMGKGMKRV
Specificity	A synthetic peptide corresponding to a sequence within amino acids 528-627 of human L-Plastin/LCP1 (P13796).

Tissue Specificity	Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
Post Translational Modifications	Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.
Function	Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
Protein Name	Plastin-2 L-Plastin Lc64p Lymphocyte Cytosolic Protein 1 Lcp-1
Database Links	Reactome: R-HSA-8950505
Cellular Localisation	Cytoplasm Cytoskeleton Cell Junction Cell Projection Ruffle Membrane Peripheral Membrane Protein Cytoplasmic Side Relocalizes To The Immunological Synapse Between Peripheral Blood T-Lymphocytes And Antibody-Presenting Cells In Response To Costimulation Through Tcr/Cd3 And Cd2 Or Cd28 Associated With The Actin Cytoskeleton At Membrane Ruffles Relocalizes To Actin-Rich Cell Projections Upon Serine Phosphorylation
Alternative Antibody Names	Anti-Plastin-2 antibody Anti-L-Plastin antibody Anti-Lc64p antibody Anti-Lymphocyte Cytosolic Protein 1 antibody Anti-Lcp-1 antibody Anti-LCP1 antibody Anti-PLS2 antibody

Information sourced from Uniprot.org