Anti-KSR1 antibody (358-407 aa) (STJ93861)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KSR at the amino acid range 358-407
General Information
| Short Description | Rabbit polyclonal anti-Kinase suppressor of Ras 1 (358-407 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KSR1 |
| Gene ID | 8844 |
| Uniprot ID | KSR1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KSR at the amino acid range 358-407 |
| Immunogen Region | 358-407 aa |
| Specificity | Ksr-1 Polyclonal Antibody detects endogenous levels of Ksr-1 protein. |
Additional Info
| Function | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF.upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. |
| Protein Name | Kinase Suppressor Of Ras 1 |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCell MembraneCell ProjectionRuffle MembraneEndoplasmic Reticulum MembraneIn Unstimulated CellsWhere The Phosphorylated Form Is Bound To A 14-3-3 ProteinSequestration In The Cytoplasm OccursFollowing Growth Factor TreatmentThe Protein Is Free For Membrane TranslocationAnd It Moves From The Cytoplasm To The Cell Periphery |
| Alternative Antibody Names | Anti-Kinase Suppressor Of Ras 1 antibodyAnti-KSR1 antibodyAnti-KSR antibody |
Information sourced from Uniprot.org