Host: | Mouse |
Applications: | IF/WB/IHC |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Mouse monoclonal antibody anti-Keratin, type II cytoskeletal 8 is suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry research applications. |
Clonality : | Monoclonal |
Clone ID : | 8G8 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Liquid in PBS pH7.4, 0.5% BSA, 0.02% Sodium Azide and 50% Glycerol. |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Dilution Range: | IF 1:50-200WB 1:2000-5000IHC 1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | KRT8 |
Gene ID: | 3856 |
Uniprot ID: | K2C8_HUMAN |
Specificity: | The antibody detects endogenous CK8 proteins. |
Immunogen: | Synthetic Peptide of CK8 |
Post Translational Modifications | Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. |
Function | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
Protein Name | Keratin - Type Ii Cytoskeletal 8Cytokeratin-8Ck-8Keratin-8K8Type-Ii Keratin Kb8 |
Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
Cellular Localisation | CytoplasmNucleusNucleoplasmNucleus Matrix |
Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 8 antibodyAnti-Cytokeratin-8 antibodyAnti-Ck-8 antibodyAnti-Keratin-8 antibodyAnti-K8 antibodyAnti-Type-Ii Keratin Kb8 antibodyAnti-KRT8 antibodyAnti-CYK8 antibody |
Information sourced from Uniprot.org