| Tissue Specificity | Expressed in corneal epithelium (at protein level). Expressed in keratinocytes (at protein level). |
| Post Translational Modifications | Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle. Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis. CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury. O-glycosylated. |
| Function | Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes. |
| Protein Name | Keratin - Type Ii Cytoskeletal 558 Kda CytokeratinCytokeratin-5Ck-5Keratin-5K5Type-Ii Keratin Kb5 |
| Database Links | Reactome: R-HSA-446107Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 5 antibodyAnti-58 Kda Cytokeratin antibodyAnti-Cytokeratin-5 antibodyAnti-Ck-5 antibodyAnti-Keratin-5 antibodyAnti-K5 antibodyAnti-Type-Ii Keratin Kb5 antibodyAnti-KRT5 antibody |
Information sourced from Uniprot.org
