• Confocal immunofluorescence analysis of A-431 cells using Cytokeratin 20 (Cytokeratin 20 (KRT20) ) antibody (STJ24356) at dilution of 1:200. Blue: DAPI for nuclear staining.

Anti-KRT20 antibody (245-424) (STJ24356)

SKU:
STJ24356

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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KRT20 (245-424) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KRT20
Gene ID: 54474
Uniprot ID: K1C20_HUMAN
Immunogen Region: 245-424
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 245-424 of human Cytokeratin 20 (Cytokeratin 20 (KRT20) ) (NP_061883.1).
Immunogen Sequence: KYEVMAQKNLQEAKEQFERQ TAVLQQQVTVNTEELKGTEV QLTELRRTSQSLEIELQSHL SMKESLEHTLEETKARYSSQ LANLQSLLSSLEAQLMQIRS NMERQNNEYHILLDIKTRLE QEIATYRRLLEGEDVKTTEY QLSTLEERDIKKTRKIKTVV QEVVDGKVVSSEVKEVEENI
Tissue Specificity Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa.specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
Post Translational Modifications Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury. Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
Function Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.
Protein Name Keratin - Type I Cytoskeletal 20
Cytokeratin-20
Ck-20
Keratin-20
K20
Protein It
Database Links Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Keratin - Type I Cytoskeletal 20 antibody
Anti-Cytokeratin-20 antibody
Anti-Ck-20 antibody
Anti-Keratin-20 antibody
Anti-K20 antibody
Anti-Protein It antibody
Anti-KRT20 antibody

Information sourced from Uniprot.org

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