| Background | Cytokeratin 19 is a member of type I acidic subfamily of intermediate filaments. It is expressed in various different humantissuesexcept in liver. Keratin 19 is not expressed in hepatocytes, therefore, antibody to CK19 is useful inthe identification of liver metastasis.BA17reacts with the MCF‐7 cells, which are known to contain CK19. It shows no reaction with the cells lacking CK19 such as A431 and HeLa.In combinationwith HBME1, CK19 is useful in differentiating thyroid carcinoma from benign thyroid follicles. |
| Tissue Specificity | Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. |
| Function | Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| Database Links | Reactome: R-HSA-6805567 |
| Protein Name | Keratin - Type I Cytoskeletal 19Cytokeratin-19Ck-19Keratin-19K19 |
| Alternative Names | Anti-Keratin - Type I Cytoskeletal 19 antibodyAnti-Cytokeratin-19 antibodyAnti-Ck-19 antibodyAnti-Keratin-19 antibodyAnti-K19 antibodyAnti-KRT19 antibody |
| Positive Control | Skin. |
Information sourced from Uniprot.org
