• Formalin-fixed, paraffin-embedded human pancreatic ducts stained with anti-keratin 19 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of ductal cells
  • Formalin-fixed, paraffin-embedded human pancreatic ducts stained with anti-keratin 19 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of ductal cells

Anti-KRT19 antibody (STJ180143)

SKU:
STJ180143
Current Stock:
Host: Mouse
Applications: IHC-p
Reactivity: Human
Short Description: Mouse monoclonal primary antibody against KRT19.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: BA17
Conjugation: Unconjugated
Formulation: Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Isotype: IgG1 Kappa
Dilution Range: 1:100‐200
Uniprot ID: K1C19_HUMAN
Gene ID: 3880
Gene Symbol: KRT19
Immunogen: Detergent‐insoluble extract of human mammary epithelial organoids
Background Cytokeratin 19 is a member of type I acidic subfamily of intermediate filaments. It is expressed in various different humantissuesexcept in liver. Keratin 19 is not expressed in hepatocytes, therefore, antibody to CK19 is useful inthe identification of liver metastasis.BA17reacts with the MCF‐7 cells, which are known to contain CK19. It shows no reaction with the cells lacking CK19 such as A431 and HeLa.In combinationwith HBME1, CK19 is useful in differentiating thyroid carcinoma from benign thyroid follicles.
Tissue Specificity Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
Function Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Database Links Reactome: R-HSA-6805567
Protein Name Keratin - Type I Cytoskeletal 19
Cytokeratin-19
Ck-19
Keratin-19
K19
Alternative Names Anti-Keratin - Type I Cytoskeletal 19 antibody
Anti-Cytokeratin-19 antibody
Anti-Ck-19 antibody
Anti-Keratin-19 antibody
Anti-K19 antibody
Anti-KRT19 antibody
Positive Control Skin.

Information sourced from Uniprot.org

6 months standard