| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Keratin, type I cytoskeletal 10 (136-185 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KRT10 |
| Gene ID: |
3858 |
| Uniprot ID: |
K1C10_HUMAN |
| Immunogen Region: |
136-185 aa |
| Specificity: |
Cytokeratin 10 Polyclonal Antibody detects endogenous levels of Cytokeratin 10 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human Keratin 10 at the amino acid range 136-185 |
| Function | Plays a role in the establishment of the epidermal barrier on plantar skin. Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. |
| Protein Name | Keratin - Type I Cytoskeletal 10Cytokeratin-10Ck-10Keratin-10K10 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | SecretedExtracellular SpaceCell SurfaceCytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 10 antibodyAnti-Cytokeratin-10 antibodyAnti-Ck-10 antibodyAnti-Keratin-10 antibodyAnti-K10 antibodyAnti-KRT10 antibodyAnti-KPP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
