| Host: | Mouse |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Keratin, type II cytoskeletal 1 (200-300 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-CK1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KRT1 |
| Gene ID: | 3848 |
| Uniprot ID: | K2C1_HUMAN |
| Immunogen Region: | 200-300 aa |
| Specificity: | This antibody detects endogenous levels of human Cytokeratin 1. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section. The a |
| Immunogen: | Synthesized peptide derived from the human Cytokeratin 1 at the amino acid range 200-300 |
| Post Translational Modifications | Undergoes deimination of some arginine residues (citrullination). |
| Function | May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. |
| Protein Name | Keratin - Type Ii Cytoskeletal 167 Kda CytokeratinCytokeratin-1Ck-1Hair Alpha ProteinKeratin-1K1Type-Ii Keratin Kb1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembraneCytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 1 antibodyAnti-67 Kda Cytokeratin antibodyAnti-Cytokeratin-1 antibodyAnti-Ck-1 antibodyAnti-Hair Alpha Protein antibodyAnti-Keratin-1 antibodyAnti-K1 antibodyAnti-Type-Ii Keratin Kb1 antibodyAnti-KRT1 antibodyAnti-KRTA antibody |
Information sourced from Uniprot.org
