Anti-KPNA5 antibody (1-240) (STJ29470)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KPNA5 (1-240) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KPNA5 |
| Gene ID | 3841 |
| Uniprot ID | IMA6_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MDAMASPGKDNYRMKSYKNK ALNPQEMRRRREEEGIQLRK QKREEQLFKRRNVYLPRNDE SMLESPIQDPDISSTVPIPE EEVVTTDMVQMIFSNNADQQ LTATQKFRKLLSKEPNPPID QVIQKPGVVQRFVKFLERNE NCTLQFEAAWALTNIASGTF LHTKVVIETGAVPIFIKLLN SEHEDVQEQAVWALGNIAGD NAECRDFVLNCEILPPLLEL LTNSNRLTTTRNAVWALSN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human KPNA5 (NP_002260.2). |
Additional Info
| Tissue Specificity | Testis. |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. |
| Protein Name | Importin Subunit Alpha-6Karyopherin Subunit Alpha-5 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-168276 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Importin Subunit Alpha-6 antibodyAnti-Karyopherin Subunit Alpha-5 antibodyAnti-KPNA5 antibody |
Information sourced from Uniprot.org