| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | KMT2D |
| Gene ID: | 8085 |
| Uniprot ID: | KMT2D_HUMAN |
| Immunogen Region: | 155-330 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 155-330 of human KMT2D (NP_003473.3). |
| Immunogen Sequence: | PELCGVDKAIFSGISQRCSH CTRLGASIPCRSPGCPRLYH FPCATASGSFLSMKTLQLLC PEHSEGAAYLEEARCAVCEG PGELCDLFFCTSCGHHYHGA CLDTALTARKRAGWQCPECK VCQACRKPGNDSKMLVCETC DKGYHTFCLKPPMEELPAHS WKCKACRVCRACGAGS |
| Tissue Specificity | Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver. |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. |
| Protein Name | Histone-Lysine N-Methyltransferase 2dLysine N-Methyltransferase 2dAll1-Related ProteinMyeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 2 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3214841Reactome: R-HSA-3769402Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase 2d antibodyAnti-Lysine N-Methyltransferase 2d antibodyAnti-All1-Related Protein antibodyAnti-Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 2 antibodyAnti-KMT2D antibodyAnti-ALR antibodyAnti-MLL2 antibodyAnti-MLL4 antibody |
Information sourced from Uniprot.org
