Anti-KLRK1 antibody (167-216 aa) (STJ98759)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the human protein at the amino acid range 167-216
General Information
| Short Description | Rabbit polyclonal anti-NKG2-D type II integral membrane protein (167-216 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLRK1 |
| Gene ID | 22914 |
| Uniprot ID | NKG2D_HUMAN |
| Immunogen | Synthetic peptide from the human protein at the amino acid range 167-216 |
| Immunogen Region | 167-216 aa |
| Specificity | The antibody detects endogenous CD314 |
Additional Info
| Function | Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
| Protein Name | Nkg2-D Type Ii Integral Membrane ProteinKiller Cell Lectin-Like Receptor Subfamily K Member 1Nk Cell Receptor DNkg2-D-Activating Nk ReceptorCd Antigen Cd314 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-2172127Reactome: R-HSA-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinColocalized With Hcst On The Cell Surface |
| Alternative Antibody Names | Anti-Nkg2-D Type Ii Integral Membrane Protein antibodyAnti-Killer Cell Lectin-Like Receptor Subfamily K Member 1 antibodyAnti-Nk Cell Receptor D antibodyAnti-Nkg2-D-Activating Nk Receptor antibodyAnti-Cd Antigen Cd314 antibodyAnti-KLRK1 antibodyAnti-D12S2489E antibodyAnti-NKG2D antibody |
Information sourced from Uniprot.org