| Function | Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation. |
| Protein Name | Nkg2-C Type Ii Integral Membrane ProteinCd159 Antigen-Like Family Member CNk Cell Receptor CNkg2-C-Activating Nk ReceptorCd Antigen Cd159c |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Nkg2-C Type Ii Integral Membrane Protein antibodyAnti-Cd159 Antigen-Like Family Member C antibodyAnti-Nk Cell Receptor C antibodyAnti-Nkg2-C-Activating Nk Receptor antibodyAnti-Cd Antigen Cd159c antibodyAnti-KLRC2 antibodyAnti-NKG2C antibody |
Information sourced from Uniprot.org
