Anti-KLK11 antibody (1-250) (STJ28724)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KLK11 (1-250) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLK11 |
| Gene ID | 11012 |
| Uniprot ID | KLK11_HUMAN |
| Immunogen Region | 1-250 |
| Immunogen Sequence | MRILQLILLALATGLVGGET RIIKGFECKPHSQPWQAALF EKTRLLCGATLIAPRWLLTA AHCLKPRYIVHLGQHNLQKE EGCEQTRTATESFPHPGFNN SLPNKDHRNDIMLVKMASPV SITWAVRPLTLSSRCVTAGT SCLISGWGSTSSPQLRLPHT LRCANITIIEHQKCENAYPG NITDTMVCASVQEGGKDSCQ GDSGGPLVCNQSLQGIISWG QDPCAITRKPGVYTKVCKY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human KLK11 (NP_001129504.1). |
Additional Info
| Tissue Specificity | Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). |
| Post Translational Modifications | About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen. |
| Function | Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. |
| Protein Name | Kallikrein-11Hk11HippostasinSerine Protease 20Trypsin-Like Protease Cleaved Into - Kallikrein-11 Inactive Chain 1 - Kallikrein-11 Inactive Chain 2 |
| Database Links | |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Golgi ApparatusSecreted |
| Alternative Antibody Names | Anti-Kallikrein-11 antibodyAnti-Hk11 antibodyAnti-Hippostasin antibodyAnti-Serine Protease 20 antibodyAnti-Trypsin-Like Protease Cleaved Into - Kallikrein-11 Inactive Chain 1 - Kallikrein-11 Inactive Chain 2 antibodyAnti-KLK11 antibodyAnti-PRSS20 antibodyAnti-TLSP antibodyAnti-UNQ649 antibodyAnti-PRO1279 antibody |
Information sourced from Uniprot.org