Anti-KLHL41 antibody (268-318 aa) (STJ194907)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human KBTBA at the amino acid range 268-318
General Information
| Short Description | Rabbit polyclonal anti-Kelch-like protein 41 (268-318 aa) for use in WB and IHC in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLHL41 |
| Gene ID | 10324 |
| Uniprot ID | KLH41_HUMAN |
| Immunogen | Synthesized peptide derived from the human KBTBA at the amino acid range 268-318 |
| Immunogen Region | 268-318 aa |
| Specificity | This antibody detects endogenous levels of KBTBA at Human/Rat |
Additional Info
| Post Translational Modifications | Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. |
| Function | Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. |
| Protein Name | Kelch-Like Protein 41Kel-Like Protein 23Kelch Repeat And Btb Domain-Containing Protein 10Kelch-Related Protein 1Sarcosin |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionPseudopodiumRuffleMyofibrilSarcomereM LineSarcoplasmic Reticulum MembraneEndoplasmic Reticulum MembranePredominantly Cytoplasmic But Can Colocalize With F-Actin At The Membrane Ruffle-Like Structures At The Tips Of Transformation-Specific Pseudopodia |
| Alternative Antibody Names | Anti-Kelch-Like Protein 41 antibodyAnti-Kel-Like Protein 23 antibodyAnti-Kelch Repeat And Btb Domain-Containing Protein 10 antibodyAnti-Kelch-Related Protein 1 antibodyAnti-Sarcosin antibodyAnti-KLHL41 antibodyAnti-KBTBD10 antibodyAnti-KRP1 antibody |
Information sourced from Uniprot.org