| Post Translational Modifications | Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed. |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins. |
| Protein Name | Kelch-Like Protein 12Cul3-Interacting Protein 1Dkir HomologHdkir |
| Database Links | Reactome: R-HSA-4641258 |
| Cellular Localisation | Cytoplasmic VesicleCopii-Coated Vesicle |
| Alternative Antibody Names | Anti-Kelch-Like Protein 12 antibodyAnti-Cul3-Interacting Protein 1 antibodyAnti-Dkir Homolog antibodyAnti-Hdkir antibodyAnti-KLHL12 antibodyAnti-C3IP1 antibody |
Information sourced from Uniprot.org
