| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Kin of IRRE-like protein 1 (166-216 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIRREL1 |
| Gene ID: | 55243 |
| Uniprot ID: | KIRR1_HUMAN |
| Immunogen Region: | 166-216 aa |
| Specificity: | KIRR1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein at the amino acid range 166-216 |
| Post Translational Modifications | Phosphorylation probably regulates the interaction with NSH2. Phosphorylated at Tyr-605 and Tyr-606 by FYN, leading to GRB2 binding. N-glycosylated. |
| Function | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
| Protein Name | Kin Of Irre-Like Protein 1Kin Of Irregular Chiasm-Like Protein 1Nephrin-Like Protein 1 |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPredominantly Located At Podocyte Slit Diaphragm |
| Alternative Antibody Names | Anti-Kin Of Irre-Like Protein 1 antibodyAnti-Kin Of Irregular Chiasm-Like Protein 1 antibodyAnti-Nephrin-Like Protein 1 antibodyAnti-KIRREL1 antibodyAnti-KIRREL antibodyAnti-NEPH1 antibody |
Information sourced from Uniprot.org