| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Killer cell immunoglobulin-like receptor 2DL4 (280-360 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIR2DL4 |
| Gene ID: | 3805 |
| Uniprot ID: | KI2L4_HUMAN |
| Immunogen Region: | 280-360 aa |
| Specificity: | KI2L4 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 280-360 |
| Function | Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response. |
| Protein Name | Killer Cell Immunoglobulin-Like Receptor 2dl4 Cd158 Antigen-Like Family Member D G9p Killer Cell Inhibitory Receptor 103as Kir-103as Mhc Class I Nk Cell Receptor Kir103as Cd Antigen Cd158d |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Early Endosome Membrane |
| Alternative Antibody Names | Anti-Killer Cell Immunoglobulin-Like Receptor 2dl4 antibody Anti-Cd158 Antigen-Like Family Member D antibody Anti-G9p antibody Anti-Killer Cell Inhibitory Receptor 103as antibody Anti-Kir-103as antibody Anti-Mhc Class I Nk Cell Receptor Kir103as antibody Anti-Cd Antigen Cd158d antibody Anti-KIR2DL4 antibody Anti-CD158D antibody Anti-KIR103AS antibody |
Information sourced from Uniprot.org