| Tissue Specificity | Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain. |
| Post Translational Modifications | S-nitrosylation increases the open probability and inward rectifying currents. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. |
| Protein Name | Inward Rectifier Potassium Channel 2Cardiac Inward Rectifier Potassium ChannelInward Rectifier K(+ Channel Kir2.1Irk-1Hirk1Potassium Channel - Inwardly Rectifying Subfamily J Member 2 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296053Reactome: R-HSA-5576886Reactome: R-HSA-9729555Reactome: R-HSA-997272 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaT-Tubule |
| Alternative Antibody Names | Anti-Inward Rectifier Potassium Channel 2 antibodyAnti-Cardiac Inward Rectifier Potassium Channel antibodyAnti-Inward Rectifier K(+ Channel Kir2.1 antibodyAnti-Irk-1 antibodyAnti-Hirk1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 2 antibodyAnti-KCNJ2 antibodyAnti-IRK1 antibody |
Information sourced from Uniprot.org
