Anti-KIF7 antibody [2A7-10B8-9A9] (STJA0032778)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenSynthetic Peptide of Kif 7
General Information
| Short Description | Mouse monoclonal anti-KIF7 for use in IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ICC/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2A7-10B8-9A9 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | KIF7 |
| Gene ID | 374654 |
| Uniprot ID | KIF7_HUMAN |
| Immunogen | Synthetic Peptide of Kif 7 |
Additional Info
| Tissue Specificity | Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. |
| Post Translational Modifications | Polyubiquitinated by UBR3. |
| Function | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation. Involved in the regulation of epidermal differentiation and chondrocyte development. |
| Protein Name | Kinesin-Like Protein Kif7 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5632684 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyLocalizes To The Cilium Tip |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif7 antibodyAnti-KIF7 antibodyAnti-UNQ340 antibodyAnti-PRO539 antibody |
Information sourced from Uniprot.org