• Immunofluorescence analysis of A549 cells, using KIF2C Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-KIF2C antibody (61-110 aa) (STJ93836)

SKU:
STJ93836

Current Stock:
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Kinesin-like protein KIF2C (61-110 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KIF2C
Gene ID: 11004
Uniprot ID: KIF2C_HUMAN
Immunogen Region: 61-110 aa
Specificity: KIF2C Polyclonal Antibody detects endogenous levels of KIF2C protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human KIF2C at the amino acid range 61-110
Post Translational Modifications Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity. Ubiquitinated.
Function In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.
Protein Name Kinesin-Like Protein Kif2c
Kinesin-Like Protein 6
Mitotic Centromere-Associated Kinesin
Mcak
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2132295
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-5663220
Reactome: R-HSA-6811434
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Reactome: R-HSA-983189
Cellular Localisation Cytoplasm
Cytoskeleton
Nucleus
Chromosome
Centromere
Kinetochore
Associates With The Microtubule Network At The Growing Distal Tip (The Plus-End) Of Microtubules
Probably Through Interaction With Mtus2/Tip150 And Mapre1
Association With Microtubule Plus Ends Is Also Mediated By Interaction With Kif18b
Centromeric Localization Requires The Presence Of Bub1 And Sgo2
Alternative Antibody Names Anti-Kinesin-Like Protein Kif2c antibody
Anti-Kinesin-Like Protein 6 antibody
Anti-Mitotic Centromere-Associated Kinesin antibody
Anti-Mcak antibody
Anti-KIF2C antibody
Anti-KNSL6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance