| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIF2B |
| Gene ID: | 84643 |
| Uniprot ID: | KIF2B_HUMAN |
| Immunogen Region: | 544-673 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 544-673 of human KIF2B (NP_115948.4). |
| Immunogen Sequence: | NVDVRPYHRGHYPIGHEAPR MLKSHIGNSEMSLQRDEFIK IPYVQSEEQKEIEEVETLPT LLGKDTTISGKGSSQWLENI QERAGGVHHDIDFCIARSLS ILEQKIDALTEIQKKLKLLL ADLHVKSKVE |
| Tissue Specificity | Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level). |
| Post Translational Modifications | Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase. |
| Function | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression. |
| Protein Name | Kinesin-Like Protein Kif2b |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-6811434Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleChromosomeCentromereKinetochoreAssociation With Kinetochore Is Transient |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif2b antibodyAnti-KIF2B antibody |
Information sourced from Uniprot.org
