| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | KIF23 |
| Gene ID: | 9493 |
| Uniprot ID: | KIF23_HUMAN |
| Immunogen Region: | 700-950 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-950 of human KIF23 (NP_612565.1). |
| Immunogen Sequence: | NGQQLMSQPQLHRRSNSCSS ISVASCISEWEQKIPTYNTP LKVTSIARRRQQEPGQSKTC IVSDRRRGMYWTEGREVVPT FRNEIEIEEDHCGRLLFQPD QNAPPIRLRHRRSRSAGDRW VDHKPASNMQTETVMQPHVP HAITVSVANEKALAKCEKYM LTHQELASDGEIETKLIKGD IYKTRGGGQSVQFTDIETLK QESPNGSRKRRSSTVAPAQP DGAESEWTDVETRCSVAVE |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated. Deubiquitinated by USP8/UBPY. |
| Function | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. |
| Protein Name | Kinesin-Like Protein Kif23 Kinesin-Like Protein 5 Mitotic Kinesin-Like Protein 1 |
| Database Links | Reactome: R-HSA-2132295 Reactome: R-HSA-6811434 Reactome: R-HSA-68884 Reactome: R-HSA-983189 |
| Cellular Localisation | Nucleus Cytoplasm Cytoskeleton Spindle Midbody Midbody Ring Localizes To The Interzone Of Mitotic Spindles Detected At The Midbody During Later Stages Of Mitotic Cytokinesis |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif23 antibody Anti-Kinesin-Like Protein 5 antibody Anti-Mitotic Kinesin-Like Protein 1 antibody Anti-KIF23 antibody Anti-KNSL5 antibody Anti-MKLP1 antibody |
Information sourced from Uniprot.org