| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KIF20B (1200-1500) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KIF20B |
| Gene ID: |
9585 |
| Uniprot ID: |
KI20B_HUMAN |
| Immunogen Region: |
1200-1500 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1200-1500 of human KIF20B (NP_057279.2). |
| Immunogen Sequence: |
KHLLQLKEEEEETNRQETEK LKEELSASSARTQNLKADLQ RKEEDYADLKEKLTDAKKQI KQVQKEVSVMRDEDKLLRIK INELEKKKNQCSQELDMKQR TIQQLKEQLNNQKVEEAIQQ YERACKDLNVKEKIIEDMRM TLEEQEQTQVEQDQVLEAKL EEVERLATELEKWKEKCNDL ETKNNQRSNKEHENNTDVLG KLTNLQDELQESEQKYNADR KKWLEEKMMLITQAKEAEN |
| Tissue Specificity | Brain, ovary, kidney and testis (at protein level). Overexpressed in bladder cancer cells (at protein level). Expressed in testis. Overexpressed in bladder cancer cells. |
| Post Translational Modifications | Phosphorylated during mitosis by CDK1. |
| Function | Plus-end-directed motor enzyme that is required for completion of cytokinesis. Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. |
| Protein Name | Kinesin-Like Protein Kif20bCancer/Testis Antigen 90Ct90Kinesin Family Member 20bKinesin-Related Motor Interacting With Pin1M-Phase Phosphoprotein 1Mpp1 |
| Database Links | Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleolusNucleoplasmSpindleSpindle PoleMidbodyCell ProjectionAxonGrowth ConeLocalizes Mainly In The Nucleus During Interphase Although It Is Also Detected In The Cytoplasm Without Clear Association With MicrotubulesLocalized To The Central Spindle During Cytokinetic Furrowing And With The Midbody During AbscissionA 2-3 Fold Expression Increase Is Seen As Cells Progress From G1 To G2/M PhaseDuring Prophase And Metaphase It Is Found Throughout The Cytoplasm And At Anaphase Accumulates At The Midplan Of The Cell And Forms A Distinct Band Extending Across The Spindle MidzoneAt Anaphase It Is Concentrated In The MidbodyColocalized Partially Along Microtubules In Primary NeuronsColocalized With Shtn1 Along Microtubules To The Tip Of The Growing Cone In Primary Hippocampal NeuronsLocalized In Midbodies Between Dividing Radial Progenitors In The Ventricular ZoneColocalized With Prc1 In The Nucleus Of Bladder Carcinoma Cells At The InterphaseColocalized With Prc1 In Bladder Carcinoma Cells At ProphaseMetaphaseEarly AnaphaseAt The Midzone In Late Anaphase And At The Contractile Ring In Telophase |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif20b antibodyAnti-Cancer/Testis Antigen 90 antibodyAnti-Ct90 antibodyAnti-Kinesin Family Member 20b antibodyAnti-Kinesin-Related Motor Interacting With Pin1 antibodyAnti-M-Phase Phosphoprotein 1 antibodyAnti-Mpp1 antibodyAnti-KIF20B antibodyAnti-KRMP1 antibodyAnti-MPHOSPH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
