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Anti-keratin 18 antibody (Internal) (STJ73363)

STJ73363 (0. 1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
STJ73363 (0. 1µg/ml) staining of Pig Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

Anti-keratin 18 antibody (Internal) (STJ73363)

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STJ73363-100

£303.50

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General Information
Product Properties
Target Information
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Host:	Goat
Applications:	Pep-ELISA/WB/IHC
Reactivity:	Human/Mouse/Rat/Dog/Pig/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-keratin 18 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-5µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	KRT18
Gene ID:	3875
Uniprot ID:	K1C18_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_000215.1
Specificity:	Reported variants represent identical protein: NP_000215.1, NP_954657.1.
Immunogen Sequence:	EELDKYWSQQIE

Post Translational Modifications	Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.
Function	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Protein Name	Keratin - Type I Cytoskeletal 18 Cell Proliferation-Inducing Gene 46 Protein Cytokeratin-18 Ck-18 Keratin-18 K18
Database Links	Reactome: R-HSA-6805567 Reactome: R-HSA-6809371
Cellular Localisation	Nucleus Matrix Cytoplasm Perinuclear Region Nucleus Nucleolus
Alternative Antibody Names	Anti-Keratin - Type I Cytoskeletal 18 antibody Anti-Cell Proliferation-Inducing Gene 46 Protein antibody Anti-Cytokeratin-18 antibody Anti-Ck-18 antibody Anti-Keratin-18 antibody Anti-K18 antibody Anti-KRT18 antibody Anti-CYK18 antibody Anti-PIG46 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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