Anti-KEO4/ERLIN1 antibody (C-Term) (STJ71953)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-KEO4/ERLIN1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 38kDa band observed in Human Placenta lysates (calculated MW of 39.2kDa according to NP_006450.2). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ERLIN1 |
| Gene ID | 10613 |
| Uniprot ID | ERLN1_HUMAN |
| Accession Number | NP_006450.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | EALEPSGENVIQNKE |
| Specificity | Reported variants represent identical protein: NP_006450.2, NP_001094096.1 |
Additional Info
| Post Translational Modifications | Deubiquitinated by USP25.leading to stabilization. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. |
| Protein Name | Erlin-1Endoplasmic Reticulum Lipid Raft-Associated Protein 1Protein Ke04Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1Spfh Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5678895 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-1 antibodyAnti-Endoplasmic Reticulum Lipid Raft-Associated Protein 1 antibodyAnti-Protein Ke04 antibodyAnti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 antibodyAnti-Spfh Domain-Containing Protein 1 antibodyAnti-ERLIN1 antibodyAnti-C10orf69 antibodyAnti-KE04 antibodyAnti-KEO4 antibodyAnti-SPFH1 antibody |
Information sourced from Uniprot.org