| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-KEO4/ERLIN1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000. WB: Approx 38kDa band observed in Human Placenta lysates (calculated MW of 39.2kDa according to NP_006450.2). Recommended concentration: 0.3-1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ERLIN1 |
| Gene ID: | 10613 |
| Uniprot ID: | ERLN1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_006450.2 |
| Specificity: | Reported variants represent identical protein: NP_006450.2, NP_001094096.1 |
| Immunogen Sequence: | EALEPSGENVIQNKE |
| Post Translational Modifications | Deubiquitinated by USP25.leading to stabilization. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. |
| Protein Name | Erlin-1 Endoplasmic Reticulum Lipid Raft-Associated Protein 1 Protein Ke04 Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 Spfh Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-382556 Reactome: R-HSA-5678895 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Associated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-1 antibody Anti-Endoplasmic Reticulum Lipid Raft-Associated Protein 1 antibody Anti-Protein Ke04 antibody Anti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 antibody Anti-Spfh Domain-Containing Protein 1 antibody Anti-ERLIN1 antibody Anti-C10orf69 antibody Anti-KE04 antibody Anti-KEO4 antibody Anti-SPFH1 antibody |
Information sourced from Uniprot.org