Anti-KDM5C antibody [2E4-E1-G8] (STJA0032337)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenPurified recombinant human KDM5C/Jarid1C/SMCX protein fragments expressed in E.coli
General Information
| Short Description | Mouse monoclonal anti-KDM5C for use in WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2E4-E1-G8 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 5.7 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | KDM5C |
| Gene ID | 8242 |
| Uniprot ID | KDM5C_HUMAN |
| Immunogen | Purified recombinant human KDM5C/Jarid1C/SMCX protein fragments expressed in E.coli |
Additional Info
| Tissue Specificity | Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. |
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. |
| Protein Name | Lysine-Specific Demethylase 5cHistone Demethylase Jarid1cJumonji/Arid Domain-Containing Protein 1cProtein SmcxProtein Xe169Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5c antibodyAnti-Histone Demethylase Jarid1c antibodyAnti-Jumonji/Arid Domain-Containing Protein 1c antibodyAnti-Protein Smcx antibodyAnti-Protein Xe169 antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c antibodyAnti-KDM5C antibodyAnti-DXS1272E antibodyAnti-JARID1C antibodyAnti-SMCX antibodyAnti-XE169 antibody |
Information sourced from Uniprot.org