Anti-KDM5B antibody (1400-1544) (STJ116039)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal JARID1B (1400-1544) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM5B |
| Gene ID | 10765 |
| Uniprot ID | KDM5B_HUMAN |
| Immunogen Region | 1400-1544 |
| Immunogen Sequence | RDGINSLERKLKRRLEREGL SSERWERVKKMRTPKKKKIK LSHPKDMNNFKLERERSYEL VRSAETHSLPSDTSYSEQED SEDEDAICPAVSCLQPEGDE V |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1500 of human JARID1B (NP_006609.3). |
Additional Info
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). |
| Function | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. |
| Protein Name | Lysine-Specific Demethylase 5bCancer/Testis Antigen 31Ct31Histone Demethylase Jarid1bJumonji/Arid Domain-Containing Protein 1bPlu-1Retinoblastoma-Binding Protein 2 Homolog 1Rbp2-H1Histone H3-Trimethyl-L-Lysine(4 Demethylase 5b |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-8866911Reactome: R-HSA-9821002 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5b antibodyAnti-Cancer/Testis Antigen 31 antibodyAnti-Ct31 antibodyAnti-Histone Demethylase Jarid1b antibodyAnti-Jumonji/Arid Domain-Containing Protein 1b antibodyAnti-Plu-1 antibodyAnti-Retinoblastoma-Binding Protein 2 Homolog 1 antibodyAnti-Rbp2-H1 antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5b antibodyAnti-KDM5B antibodyAnti-JARID1B antibodyAnti-PLU1 antibodyAnti-RBBP2H1 antibody |
Information sourced from Uniprot.org