| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
KDM4D |
| Gene ID: |
55693 |
| Uniprot ID: |
KDM4D_HUMAN |
| Immunogen Region: |
1-130 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human KDM4D (NP_060509.2). |
| Immunogen Sequence: |
METMKSKANCAQNPNCNIMI FHPTKEEFNDFDKYIAYMES QGAHRAGLAKIIPPKEWKAR ETYDNISEILIATPLQQVAS GRAGVFTQYHKKKKAMTVGE YRHLANSKKYQTPPHQNFED LERKYWKNRI |
| Post Translational Modifications | Ubiquitinated via 'Lys-63'-linked ubiquitin chains. Deubiquitinated by USP14 with the help of TRIM14 leading to stabilization. |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Protein Name | Lysine-Specific Demethylase 4dJmjc Domain-Containing Histone Demethylation Protein 3dJumonji Domain-Containing Protein 2dHistone H3-Trimethyl-L-Lysine(9 Demethylase 4d |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 4d antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 3d antibodyAnti-Jumonji Domain-Containing Protein 2d antibodyAnti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4d antibodyAnti-KDM4D antibodyAnti-JHDM3D antibodyAnti-JMJD2D antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
