Anti-KDM4C antibody (640-830) (STJ110783)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KDM4C (640-830) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM4C |
| Gene ID | 23081 |
| Uniprot ID | KDM4C_HUMAN |
| Immunogen Region | 640-830 |
| Immunogen Sequence | RMKPHCAICTLLMPYHKPDS SNEENDARWETKLDEVVTSE GKTKPLIPEMCFIYSEENIE YSPPNAFLEEDGTSLLISCA KCCVRVHASCYGIPSHEICD GWLCARCKRNAWTAECCLCN LRGGALKQTKNNKWAHVMCA VAVPEVRFTNVPERTQIDVG RIPLQRLKLKCIFCRHRVKR VSGACIQCSYG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 640-830 of human KDM4C (NP_055876.2). |
Additional Info
| Tissue Specificity | Overexpressed in several esophageal squamous cell carcinomas (ESCs). |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Protein Name | Lysine-Specific Demethylase 4cGene Amplified In Squamous Cell Carcinoma 1 ProteinGasc-1 ProteinJmjc Domain-Containing Histone Demethylation Protein 3cJumonji Domain-Containing Protein 2cHistone H3-Trimethyl-L-Lysine(9 Demethylase 4c |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5625886 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 4c antibodyAnti-Gene Amplified In Squamous Cell Carcinoma 1 Protein antibodyAnti-Gasc-1 Protein antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 3c antibodyAnti-Jumonji Domain-Containing Protein 2c antibodyAnti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4c antibodyAnti-KDM4C antibodyAnti-GASC1 antibodyAnti-JHDM3C antibodyAnti-JMJD2C antibodyAnti-KIAA0780 antibody |
Information sourced from Uniprot.org