| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KDM3A (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KDM3A |
| Gene ID: |
55818 |
| Uniprot ID: |
KDM3A_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human KDM3A (NP_060903.2). |
| Immunogen Sequence: |
MVLTLGESWPVLVGRRFLSL SAADGSDGSHDSWDVERVAE WPWLSGTIRAVSHTDVTKKD LKVCVEFDGESWRKRRWIEV YSLLRRAFLVEHNLVLAERK SPEISERIVQWPAITYKPLL DKAGLGSITSVRFLGDQQRV FLSKDLLKPIQDVNSLRLSL TDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSL DPSTQWFSATVINGNPASKT LQVNCEEIPALKIVDPSLI |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. |
| Protein Name | Lysine-Specific Demethylase 3aJmjc Domain-Containing Histone Demethylation Protein 2aJumonji Domain-Containing Protein 1aHistone H3-Dimethyl-L-Lysine(9 Demethylase 3a |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-9029569 |
| Cellular Localisation | CytoplasmNucleusNuclear In Round SpermatidsWhen Spermatids Start To ElongateLocalizes To The Cytoplasm Where It Forms Distinct Foci Which Disappear In Mature Spermatozoa |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 3a antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 2a antibodyAnti-Jumonji Domain-Containing Protein 1a antibodyAnti-Histone H3-Dimethyl-L-Lysine(9 Demethylase 3a antibodyAnti-KDM3A antibodyAnti-JHDM2A antibodyAnti-JMJD1 antibodyAnti-JMJD1A antibodyAnti-KIAA0742 antibodyAnti-TSGA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
