| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Rat/Mouse/Marmoset |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNMA1 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Kcnma1 |
| Gene ID: |
16531 |
| Uniprot ID: |
KCMA1_MOUSE |
| Specificity: |
Specific for KCNMA1. |
| Immunogen: |
A synthetic peptide from rat KCNMA1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse. |
| Function | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Isoform 2: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Isoform 3: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Isoform 4: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). |
| Protein Name | Calcium-Activated Potassium Channel Subunit Alpha-1Bk ChannelBkca AlphaCalcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1K(VcaalphaKca1.1Maxi K ChannelMaxikSlo-AlphaSlo1Mslo1Slowpoke HomologSlo HomologMslo |
| Database Links | Reactome: R-MMU-1296052 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Alpha-1 antibodyAnti-Bk Channel antibodyAnti-Bkca Alpha antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1 antibodyAnti-K(Vcaalpha antibodyAnti-Kca1.1 antibodyAnti-Maxi K Channel antibodyAnti-Maxik antibodyAnti-Slo-Alpha antibodyAnti-Slo1 antibodyAnti-Mslo1 antibodyAnti-Slowpoke Homolog antibodyAnti-Slo Homolog antibodyAnti-Mslo antibodyAnti-Kcnma1 antibodyAnti-Kcnma antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
