Anti-KCNMA1 antibody (721-770 aa) (STJ94031)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MaxiKalpha at the amino acid range 721-770
General Information
| Short Description | Rabbit polyclonal anti-Calcium-activated potassium channel subunit alpha-1alpha (721-770 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNMA1 |
| Gene ID | 3778 |
| Uniprot ID | KCMA1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MaxiKalpha at the amino acid range 721-770 |
| Immunogen Region | 721-770 aa |
| Specificity | MaxiK Alpha Polyclonal Antibody detects endogenous levels of MaxiK Alpha protein. |
Additional Info
| Post Translational Modifications | Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity. Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network. |
| Function | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Possibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic transmission. Isoform 5: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). |
| Protein Name | Calcium-Activated Potassium Channel Subunit Alpha-1Bk ChannelBkca AlphaCalcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1K(VcaalphaKca1.1Maxi K ChannelMaxikSlo-AlphaSlo1Slowpoke HomologSlo HomologHslo |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457Reactome: R-HSA-9662360Reactome: R-HSA-9667769 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Alpha-1 antibodyAnti-Bk Channel antibodyAnti-Bkca Alpha antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1 antibodyAnti-K(Vcaalpha antibodyAnti-Kca1.1 antibodyAnti-Maxi K Channel antibodyAnti-Maxik antibodyAnti-Slo-Alpha antibodyAnti-Slo1 antibodyAnti-Slowpoke Homolog antibodyAnti-Slo Homolog antibodyAnti-Hslo antibodyAnti-KCNMA1 antibodyAnti-KCNMA antibodyAnti-SLO antibody |
Information sourced from Uniprot.org