| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNK9 |
| Gene ID: |
51305 |
| Uniprot ID: |
KCNK9_HUMAN |
| Immunogen Region: |
265-374 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 265-374 of human KCNK9 (NP_001269463.1). |
| Immunogen Sequence: |
AGNRNSMVIHIPEEPRPSRP RYKADVPDLQSVCSCTCYRS QDYGGRSVAPQNSFSAKLAP HYFHSISYKIEEISPSTLKN SLFPSPISSISPGLHSFTDH QRLMKRRKSV |
| Tissue Specificity | Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung. |
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials. In granule neurons, hyperpolarizes the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, supports high-frequency action potential firing and increased neuronal excitability. Homomeric and/or heteromeric KCNK3:KCNK9 channels operate in cerebellar granule cells, whereas heteromeric KCNK1:KCNK9 enables currents in hippocampal dentate gyrus granule neurons. Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. In retinal ganglion cells, mediates outward currents that regulate action potentials in response to acidification of the synaptic cleft. Involved in transmission of image-forming and nonimage-forming visual information in the retina. In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis. |
| Protein Name | Potassium Channel Subfamily K Member 9Acid-Sensitive Potassium Channel Protein Task-3Twik-Related Acid-Sensitive K(+ Channel 3Two Pore Potassium Channel Kt3.2Two Pore K(+ Channel Kt3.2 |
| Database Links | Reactome: R-HSA-1299316Reactome: R-HSA-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion Inner MembraneCell ProjectionDendriteColocalizes With Map2 In The Soma And Proximal Dendrites Of Dentate Gyrus Granule Cells |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 9 antibodyAnti-Acid-Sensitive Potassium Channel Protein Task-3 antibodyAnti-Twik-Related Acid-Sensitive K(+ Channel 3 antibodyAnti-Two Pore Potassium Channel Kt3.2 antibodyAnti-Two Pore K(+ Channel Kt3.2 antibodyAnti-KCNK9 antibodyAnti-TASK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
