Anti-KCNK6 antibody (240-320 aa) (STJ96152)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from TWIK-2 at the amino acid range 240-320
General Information
| Short Description | Rabbit polyclonal anti-Potassium channel subfamily K member 6 (240-320 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNK6 |
| Gene ID | 9424 |
| Uniprot ID | KCNK6_HUMAN |
| Immunogen | Synthesized peptide derived from TWIK-2 at the amino acid range 240-320 |
| Immunogen Region | 240-320 aa |
| Specificity | TWIK-2 Polyclonal Antibody detects endogenous levels of TWIK-2 protein. |
Additional Info
| Post Translational Modifications | N-glycosylation is necessary for targeting to lysosomes. |
| Function | K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system. Active in lysosomes where it regulates lysosome numbers and size. In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux. Isoform 2: Does not display channel activity. |
| Protein Name | Potassium Channel Subfamily K Member 6Inward Rectifying Potassium Channel Protein Twik-2Twik-Originated Similarity Sequence |
| Database Links | Reactome: R-HSA-1299308Reactome: R-HSA-5576886 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 6 antibodyAnti-Inward Rectifying Potassium Channel Protein Twik-2 antibodyAnti-Twik-Originated Similarity Sequence antibodyAnti-KCNK6 antibodyAnti-TOSS antibodyAnti-TWIK2 antibody |
Information sourced from Uniprot.org