| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Potassium channel subfamily K member 4 channel KT4.1 (38-88 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNK4 |
| Gene ID: |
50801 |
| Uniprot ID: |
KCNK4_HUMAN |
| Immunogen Region: |
38-88 aa |
| Specificity: |
KCNK4 (TRAAK) protein (A238) detects endogenous levels of KCNK4 (TRAAK) |
| Immunogen: |
Synthetic peptide derived from KCNK4 (TRthe amino acidK) at the amino acid range 38-88 |
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses. Permeable to other monovalent cations such as Rb(+) and Cs(+). |
| Protein Name | Potassium Channel Subfamily K Member 4Twik-Related Arachidonic Acid-Stimulated Potassium Channel ProteinTraakTwo Pore Potassium Channel Kt4.1K2p4.1Two Pore K(+ Channel Kt4.1 |
| Database Links | Reactome: R-HSA-1299503Reactome: R-HSA-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonLocalizes At The Ranvier Nodes Of Myelinated Afferent Nerves |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 4 antibodyAnti-Twik-Related Arachidonic Acid-Stimulated Potassium Channel Protein antibodyAnti-Traak antibodyAnti-Two Pore Potassium Channel Kt4.1 antibodyAnti-K2p4.1 antibodyAnti-Two Pore K(+ Channel Kt4.1 antibodyAnti-KCNK4 antibodyAnti-TRAAK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
