Anti-KCNK4 antibody (332-381 aa) (STJ96079)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KCNK4 at the amino acid range 332-381
General Information
| Short Description | Rabbit polyclonal anti-Potassium channel subfamily K member 4 channel KT4.1 (332-381 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNK4 |
| Gene ID | 50801 |
| Uniprot ID | KCNK4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KCNK4 at the amino acid range 332-381 |
| Immunogen Region | 332-381 aa |
| Specificity | TRAAK Polyclonal Antibody detects endogenous levels of TRAAK protein. |
Additional Info
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses. Permeable to other monovalent cations such as Rb(+) and Cs(+). |
| Protein Name | Potassium Channel Subfamily K Member 4Twik-Related Arachidonic Acid-Stimulated Potassium Channel ProteinTraakTwo Pore Potassium Channel Kt4.1K2p4.1Two Pore K(+ Channel Kt4.1 |
| Database Links | Reactome: R-HSA-1299503Reactome: R-HSA-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonLocalizes At The Ranvier Nodes Of Myelinated Afferent Nerves |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 4 antibodyAnti-Twik-Related Arachidonic Acid-Stimulated Potassium Channel Protein antibodyAnti-Traak antibodyAnti-Two Pore Potassium Channel Kt4.1 antibodyAnti-K2p4.1 antibodyAnti-Two Pore K(+ Channel Kt4.1 antibodyAnti-KCNK4 antibodyAnti-TRAAK antibody |
Information sourced from Uniprot.org