| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNK17 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNK17 |
| Gene ID: |
89822 |
| Uniprot ID: |
KCNKH_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for KCNK17. |
| Immunogen: |
A synthetic peptide from the c-terminal region of human KCNK17 (TALK2, TASK4, KCNKH) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. Present in the cardiac conduction system where it may regulate action potential duration and beating frequency of cardiac myocytes. Permeable to other monovalent cations such as Rb(+) and Cs(+). |
| Protein Name | Potassium Channel Subfamily K Member 172p Domain Potassium Channel Talk-2Acid-Sensitive Potassium Channel Protein Task-4Twik-Related Acid-Sensitive K(+ Channel 4Twik-Related Alkaline Ph-Activated K(+ Channel 2Talk-2 |
| Database Links | Reactome: R-HSA-1299361Reactome: R-HSA-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 17 antibodyAnti-2p Domain Potassium Channel Talk-2 antibodyAnti-Acid-Sensitive Potassium Channel Protein Task-4 antibodyAnti-Twik-Related Acid-Sensitive K(+ Channel 4 antibodyAnti-Twik-Related Alkaline Ph-Activated K(+ Channel 2 antibodyAnti-Talk-2 antibodyAnti-KCNK17 antibodyAnti-TALK2 antibodyAnti-TASK4 antibodyAnti-UNQ5816 antibodyAnti-PRO19634 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
