| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNK13 (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNK13 |
| Gene ID: |
56659 |
| Uniprot ID: |
KCNKD_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
Specific for KCNK13. |
| Immunogen: |
A synthetic peptide from the n-terminal of mouse KCNK13 conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat and human. |
| Function | K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. Contributes most of K(+) currents at the plasma membrane of resting microglia. Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses. Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release. |
| Protein Name | Potassium Channel Subfamily K Member 13Tandem Pore Domain Halothane-Inhibited Potassium Channel 1Thik-1 |
| Database Links | Reactome: R-HSA-1299287Reactome: R-HSA-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 13 antibodyAnti-Tandem Pore Domain Halothane-Inhibited Potassium Channel 1 antibodyAnti-Thik-1 antibodyAnti-KCNK13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
