Anti-KCNK10 antibody (500-538 aa) (STJ13101300)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 500-538 of mouse KCNK10 (KCNKA, TREK2) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-KCNK10 (500-538 aa) for use in IHC and WB in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Kcnk10 |
| Gene ID | 72258 |
| Uniprot ID | KCNKA_MOUSE |
| Immunogen | A synthetic peptide from aa region 500-538 of mouse KCNK10 (KCNKA, TREK2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 500-538 aa |
| Specificity | Specific for KCNK10. |
Additional Info
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency. Permeable to other monovalent ions such as Rb(+) and Cs(+). |
| Protein Name | Potassium Channel Subfamily K Member 10Outward Rectifying Potassium Channel Protein Trek-2Trek-2 K(+ Channel Subunit |
| Database Links | Reactome: R-MMU-1299503Reactome: -MMU-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 10 antibodyAnti-Outward Rectifying Potassium Channel Protein Trek-2 antibodyAnti-Trek-2 K(+ Channel Subunit antibodyAnti-Kcnk10 antibody |
Information sourced from Uniprot.org