| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-KCNJ8 (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | KCNJ8 |
| Gene ID: | 3764 |
| Uniprot ID: | KCNJ8_HUMAN |
| Immunogen Region: | Internal Region |
| Specificity: | Specific for KCNJ8. |
| Immunogen: | A synthetic peptide from internal region of mouse KCNJ8 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human. |
| Function | This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 8 Inward Rectifier K(+ Channel Kir6.1 Potassium Channel - Inwardly Rectifying Subfamily J Member 8 Ukatp-1 |
| Database Links | Reactome: R-HSA-1296025 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 8 antibody Anti-Inward Rectifier K(+ Channel Kir6.1 antibody Anti-Potassium Channel - Inwardly Rectifying Subfamily J Member 8 antibody Anti-Ukatp-1 antibody Anti-KCNJ8 antibody |
Information sourced from Uniprot.org