| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-KCNJ8 (Internal Region) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | KCNJ8 |
| Gene ID: | 3764 |
| Uniprot ID: | KCNJ8_HUMAN |
| Immunogen Region: | Internal Region |
| Specificity: | Specific for KCNJ8. |
| Immunogen: | A synthetic peptide from internal region of mouse KCNJ8 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with ABCC9. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 8Inward Rectifier K(+ Channel Kir6.1Potassium Channel - Inwardly Rectifying Subfamily J Member 8Ukatp-1 |
| Database Links | Reactome: R-HSA-1296025 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 8 antibodyAnti-Inward Rectifier K(+ Channel Kir6.1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 8 antibodyAnti-Ukatp-1 antibodyAnti-KCNJ8 antibody |
Information sourced from Uniprot.org